Sreemukhi (Priya Singh) decides to end her life after receiving a strange call. It is later learnt that it was a prank call by Arya (Manoj Nandan), who works for a TV channel. Arya and Sreemukhi turn out to be friends and decide to get married. After a series of events, misunderstandings arise between Arya and Sreemukhi. How they tackle the differences and unite forms the plot of Manasainodu.